Michael Kahn
Personal Information
Description
Michael Kahn, Ph.D., is a professor in the Department of Cancer Biology and Molecular Medicine at City of Hope's comprehensive cancer center. He came to City of Hope from University of Southern California, where he was the first appointed provost professor, with joint appointments in the Department of Biochemistry and Molecular Biology at Keck School of Medicine of USC and the Department of Molecular Pharmacology and Toxicology in the USC School of Pharmacy. He was also the co-leader of the GI-Oncology Program at the USC Norris Comprehensive Cancer Center, as well as the Center for Drug Discovery and Development at USC. After completing his postdoctoral training at Columbia University with Professor Gilbert Stork, Ph.D., Dr. Kahn subsequently did a second postdoctoral fellowship at the Roche Institute of Molecular Biology, where he first became interested in utilizing novel chemistry to complement and enhance the investigation of complex biological signaling pathways. Dr. Kahn’s research program is focused on the integration of basic science (biochemistry, cell and molecular biology, and chemistry) with translational medicine. His lab utilizes a forward chemical genomic strategy to identify and validate novel pharmacologic tools to study complex signaling pathways in development and disease. Utilizing a proprietary chemical library, his lab identified the first specific CBP/β-catenin antagonist ICG-001, which has been fundamental in studies involving both normal somatic stem cell and cancer stem cell biology. From a translational perspective, these studies led to the development of the second-generation CBP/β-catenin antagonist, Wnt modulating drug, PRI-724. These efforts resulted in the clinical trials of PRI-724 in Colon and Pancreatic Cancer, Leukemia, and Liver Fibrosis. His lab is currently continuing basic research investigations concerning differential Kat3 coactivator usage (i.e., CBP versus p300) in somatic stem cell biology and cancer, regenerative medicine, and aging. The lab is also investigating modulation of Wnt/β-catenin in the immune response. CBP/ β-catenin inhibitors in combination with immunotherapy may provide a significant benefit. Another area of interest to his lab is the endogenous mechanisms that control the differential usage of these coactivators and the role that the N-termini play as a nexus for the integration of a number of additional signaling pathways (e.g., STAT1/2, nuclear receptor family, RAR/RXR, Vit D) with the Wnt signaling cascade. Dr. Kahn is applying this forward chemical genomic strategy to additional critical signaling cascades with the broader goal of developing novel small molecule therapeutics. Source
Books
Freud Basico
In Basic Freud, noted psychologist Michael Kahn shows that, even in the age of psychopharmaceuticals and cognitive therapy, Freud's insights into the unconscious remain unsurpassed tools for understanding our behaviors, motivations, and emotions. In a style accessible to any lay reader or beginning student in psychology, Kahn presents key ideas such as the Oedipus complex, the repetition compulsion, guilt, anxiety, and defense mechanisms, along with recent research that has supported or expanded Freud's findings. He also presents case studies from his own work as a psychotherapist to show how Freudian thought has been instrumental in helping patients discover who they are and escape from destructive patterns. Readers aware of Freud's ideas and those discovering them for the first time will benefit from Kahn's fresh, informed, and unpretentious approach.
The tao of conversation
"Why does it always end up like this? Can't we really talk about something - without either arguing or just uh-huhing each other?" Psychologist Michael Kahn believes that we can - and that the conversations we're missing out on have the potential to dazzle and delight us all. As businesses enter the information age and our lives struggle to keep up, we can't afford not to talk to each other. And yet how many voices are cut off or silenced, at home or in the conference room, before they can even begin to be heard? This book is for anyone who has ever tried to talk to an intimate partner, co-worker, or friend, only to end up frustrated, alienated, or hurt. It doesn't have to be that way! We can all learn to overcome the combative or disengaged conversation styles that we see around us and experience the joy of exploring new ideas with others, deepening personal relationships, and releasing untapped creativity in our professional lives.
Botswana
photographs taken and compiled by Michael Kahn ; Setswana captions by David Ntsabane ; English captions by Jane Swartland ; introduction by K.M. Masogo.
Flight of the flamingos
Over the past four decades South Africa has experienced a significant outflow of research and development (R&D) workers, a mobility trend that this pioneering study analyzes to address the troubling loss of science, engineering, and technology knowledge that South Africa is currently facing.
Financing Innovation
This series of books brings together results of an extensive research programme on aspects of the national systems of innovation in the five BRICS countries – Brazil, Russia, India, China, and South Africa. It provides a comprehensive and comparative examination of the challenges and opportunities faced by these dynamic and emerging economies. In discussing the impact of innovation with respect to economic, geopolitical, socio-cultural, institutional, and technological systems, it reveals the possibilities of new development paradigms for equitable and sustainable growth. This volume analyses the financing of science, technology and innovation in the BRICS economies. It highlights the importance of institutional coordination and the influence of implicit policies on the extent to which capital markets may contribute to innovation financing. It stresses the role of state development banks and similar organisations in promoting high-risk and long-run building of innovative capacities with respect to development strategy. Original and detailed data, together with expert analyses on wide-ranging issues, make this book an invaluable resource for researchers and scholars in economics, development studies and political science, in addition to policy-makers and development practitioners interested in the BRICS countries.